Should i take cymbalta in the morning or at night

B Doses statistically significantly cymbalta superior to cymbalta and alcohol placebo. After 13 weeks take of the treatment, patients taking night cymbalta 60-120 mg daily had a cymbalta reviews should significantly greater pain reduction compared to placebo. Cymbalta can pass into your night breast milk. Serotonin Syndrome: This condition can be the life-threatening and should symptoms may include: agitation, hallucinations, coma or take other changes in mental status coordination problems or muscle twitching (overactive reflexes) racing heartbeat, high or low blood pressure sweating or fever nausea, cymbalta vomiting, or diarrhea. Alcohol may increase some serious side effects morning of Cymbalta. Antidepressant medicines can interact with night other medicines. Read More, i lowered to 60 mg a day for a few days, (I ran out. At present, Cymbalta is not approved for treating bipolar depression, but is being prescribed to people with take bipolar disorder as an off-label use. Cymbalta carry a black-box warning about should the take risk of suicide among people who use the antidepressant. For this the reason, cymbalta should not be prescribed for patients with night substantial alcohol use see warnings AND precautions should and drug interactions. The safety of doses the above 120 the mg/day has not been cymbalta weight gain adequately evaluated. While morning a 120 mg once daily dose was shown to be effective, there cymbalta withdrawal is no take evidence that doses greater than night 60 mg/day confer additional benefit. Risk Summary There are night no morning adequate and well-controlled studies of cymbalta administration in pregnant women. Mellaril together with Cymbalta can cause serious heart rhythm problems or sudden death. Table 4: Treatment-Emergent Adverse Reactions: Incidence of 2 or More and Greater than Placebo in dpnp, FM, OA, and clbp Placebo-Controlled Trialsa System Organ Class / Adverse Reaction Percentage of Patients Reporting Reaction cymbalta (N3303) Placebo (N2352) Gastrointestinal. The safety of doses above 120 mg once daily has not been evaluated see Clinical Studies. Your depression may get worse before it gets better when you start taking Cymbalta. Adverse Reactions Reported as Reasons for Discontinuation of Treatment in Adult Placebo-Controlled Trials Major Depressive Disorder Approximately.4 (319/3779) of the patients who received Cymbalta in placebo-controlled trials for MDD discontinued treatment due to an adverse reaction, compared with.6. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults night beyond age 24; there was a reduction with antidepressants compared to placebo in adults aged 65 and older. Common adverse reactions reported as a reason for discontinuation and considered to be drug-related take (as defined above) morning included nausea ( Cymbalta.0, placebo.7 and somnolence ( Cymbalta.0, placebo.0). Randomization was stratified by the patients baseline nsaids-use status. Major Depressive Disorder The efficacy of Cymbalta as a treatment for depression was established in 4 randomized, double-blind, placebo-controlled, fixed-dose studies in adult outpatients (18 to 83 years) meeting should DSM-IV criteria for major depression. Hepatic Impairment Patients with clinically evident hepatic impairment have cymbalta decreased duloxetine metabolism and elimination. Elderly patients may be at greater risk of developing hyponatremia with ssris the and snris. Cardiac Disorders Frequent: palpitations ; Infrequent: myocardial infarction and tachycardia. Side Effects of Largactil: Although side effects from Largactil are not common, they can occur. Keep a list of all medicines to show your healthcare provider. Warnings and Precautions Suicidal Thoughts and Behaviors in Children, Adolescents, and Young Adults Patients with major depressive disorder (MDD both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality). Vascular Disorders Frequent: hot flush; Infrequent: flushing, orthostatic hypotension, and peripheral coldness. Dosage For Treatment Of Fibromyalgia Administer cymbalta 60 mg once daily. Pediatric patients treated with Cymbalta in clinical trials experienced.1kg should mean decrease in weight the at 10 weeks, compared with a mean weight the gain of approximately.9 kg in placebo-treated patients. You may ask your healthcare provider or pharmacist for information about Cymbalta that is written for healthcare professionals. Therapy with Cymbalta may be resumed 24 hours after the last dose of linezolid or intravenous methylene blue should see Warnings and Precautions (.4 ). For patients for whom tolerability is a concern, a lower starting dose may be considered. A reaction was considered treatment-emergent if take it occurred for the first time or worsened while receiving therapy following baseline evaluation. About 10-16 of patients taking duloxetine and 16-24 of those taking venlafaxine experience insomnia. Tell your doctor if you have any eye conditions. Symptoms of Cymbalta withdrawal may include: Nausea and vomiting Anxiety Dizziness Headache Tingling and numbness Insomnia Sweating Nightmares Cymbalta and Weight Gain Researchers have found that Cymbalta (like many antidepressants) can cause fluctuations in weight among people taking the drug. Liver transaminase elevations resulted in the discontinuation.3 (92/34,756) of Cymbalta -treated patients. Hyponatremia Hyponatremia may occur as a result of treatment with ssris and snris, including cymbalta. Clbp-1 and clbp-3 demonstrated efficacy of Cymbalta in the treatment of chronic low back pain. It has also been found to reduce the severity of 'hot-flashes' in menopausal women. The proportion of patients who experienced a clinically significant decrease in weight (3.5) was greater in the cymbalta group than in the placebo group (14 and 6, respectively). I could eat 700 calories a day and exercise 30 night minutes a day and still not lose one pound. Your healthcare provider may need to change the dose of Cymbalta until it is the right dose for you. Figure 3: Percentage of Patients Achieving Various Levels of Pain Relief as Measured by 24-Hour Average Pain Severity -dpnp-1 Figure 4: Percentage of Patients Achieving Various Levels of Pain Relief as Measured by 24-Hour Average Pain Severity -dpnp-2 Fibromyalgia. Drugs Metabolized by CYP1A2 In vitro drug interaction studies demonstrate that duloxetine does not induce CYP1A2 activity. If you wouldlike more take information, talk with your healthcare provider. Males treated with Cymbalta experienced more difficulty cymbalta generic with ability to reach orgasm (asex Item 4) than males treated with placebo. Use of cymbalta with heavy alcohol intake may be associated with severe liver injury see warnings AND precautions. You could try phentermine or Bontril for appetite control if you wanted to try something with less side effects. Chlorpromazine changes a variety of chemicals in the brain. Effect night On Blood Pressure In adult placebo-controlled clinical trials across indications from baseline to endpoint, night cymbalta treatment was associated with mean increases.5 mm Hg in systolic blood pressure and.8 mm Hg in diastolic blood pressure. It should be noted that, in some cases, the clinical picture is consistent with serotonin syndrome see warnings AND precautions. In another study, 887 patients meeting DSM-IV-TR criteria for GAD received cymbalta 60 mg to 120 mg once daily during morning an initial 26-week open-label treatment phase. The most common reasons leading to discontinuation of Cymbalta are: nausea, dizziness, somnolence. Howell C, Wilson AD, Waring. Cymbalta can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. The percentage of patients who experience insomnia take increases with higher doses. Dual Inhibition Of CYP1A2 And CYP2D6 Concomitant administration of duloxetine 40 mg twice daily with fluvoxamine 100 mg, a potent CYP1A2 inhibitor, to CYP2D6 poor metabolizer subjects (n14) resulted in a 6-fold increase in duloxetine AUC and Cmax. I desperately need help. Patients on cymbalta experienced a statistically significantly longer time to relapse of depression than did patients on placebo (Study 5 in Figure 1). Venlafaxine has a dose-dependent effect on diastolic blood pressure, but clinically significant hypertension is only induced at doses 300 mg/day. After 7 weeks of treatment, Cymbalta patients with less than 30 reduction in average daily pain and who were able to tolerate Cymbalta 60 mg once daily had their dose of Cymbalta, in a double-blinded fashion, increased to 120 mg. In animal studies with duloxetine, fetal weights were decreased but there was no evidence of teratogenicity in pregnant rats and rabbits at oral doses administered cymbalta during the period of organogenesis up to 4 and 7 times the maximum morning recommended human. Nevertheless, if a decision is made to increase the dose beyond 60 mg once daily, increase dose in increments of 30 mg once daily. In studies up to 9 months, Cymbalta -treated pediatric patients experienced an increase in height.7 cm on average (2.2 cm increase in children 7 to 11 years of age and.3 cm increase in adolescents 12 to 17 years of age). When duloxetine was administered orally to pregnant rats and rabbits during the period of organogenesis, there was no evidence of teratogenicity at doses up to 45 mg/kg/day (4 times the maximum recommended human dose (mrhd) of 120 mg/day. Drugs Metabolized By CYP2C9 Results of in vitro studies demonstrate that duloxetine does not inhibit activity. Hyponatremia Advise should patients that hyponatremia has been reported as a result of treatment with snris and ssris, including Cymbalta. Instruct patients to talk to their healthcare provider about their alcohol consumption. Snris were developed more recently than ssris and currently there are four medications in this class approved by the FDA for use: venlafaxine (brand name: Effexor duloxetine (brand name. After 12 weeks of treatment, patients taking Cymbalta 60 mg daily had significantly greater pain reduction compared to placebo. If it isalmost time for the next dose, skip the missed dose and take your next dose at the regulartime. Use In Patients With Concomitant Illness Clinical experience with cymbalta in patients with concomitant systemic illnesses is limited. Treatment with Cymbalta 60 mg one or two times a day statistically significantly improved the endpoint mean pain scores from baseline and increased the proportion of patients with at least a 50 reduction in pain scores from baseline. When they are reabsorbed into the nerve cells, they no longer have an effect on mood. Patients were permitted up to 4 g of acetaminophen take per day as needed for pain, should in addition to Cymbalta. Patients were permitted up to 4 g of acetaminophen per day as needed for pain, in addition to cymbalta. Therefore, caution patients about operating hazardous machinery including automobiles, until they are reasonably certain that cymbalta therapy does not affect their ability to engage in such activities. Falls with serious consequences including bone fractures and hospitalizations have been reported see warnings AND precautions and adverse reactions. Because of the risk of serious ventricular arrhythmias and sudden death potentially associated with elevated plasma levels of thioridazine, cymbalta and thioridazine should not be co-administered see drug interactions. Nursing Mothers Risk Summary cymbalta is present in human milk. Most patients received doses of a total of 60 to 120 mg per day see Clinical Studies.The data below do not include results of the trial examining the efficacy of cymbalta in patients 65 years old for the treatment. Older adults may be more sensitive to the side effects of this medicine. Geriatric Use Of the 2,418 patients in premarketing clinical studies of cymbalta for MDD,.9 (143) were 65 years of age or over. Exercise caution when Cymbalta is administered to a nursing woman. Chronic Pain due to Osteoarthritis Approximately.7 (79/503) of the patients who received Cymbalta in 13-week, placebo-controlled trials for chronic pain due to OA discontinued treatment due to an adverse reaction, compared with.3 (37/508) take for placebo. Risk appears to be related to the presence of orthostatic decrease in blood pressure. Read More I was placed on Cymbalta 60 mg for chronic pain by my PCP and took it for 1 year. Falls with serious consequences including bone fractures and hospitalizations have been reported see adverse reactions and patient information. Some patients experienced a decrease in pain as early as week 1, which persisted throughout the study. Serotonin Syndrome Caution patients about the risk of serotonin syndrome with the concomitant use of Cymbalta and other serotonergic agents including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, buspirone, tryptophan, amphetamines, and. Diabetic Peripheral Neuropathic Pain The most commonly observed cymbalta adverse reactions in Cymbalta -treated patients (as defined above) were nausea, somnolence, decreased appetite, constipation, hyperhidrosis, and dry mouth. Subsequently, the physician may continue decreasing the dose but at a more gradual rate see dosage AND administration. The fixed-dose study the evaluated cymbalta doses of 60 mg once daily (N168) and 120 mg once daily (N170) compared to placebo (N175) over a 9week treatment period. Bymaster FP, Dreshfield-Ahmad LJ, Threlkeld PG, Shaw JL, Thompson L, Nelson DL, Hemrick-Luecke SK, Wong mparative take affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. I had always heard hormones are something very delicate that can be knocked out of kilter very easily. Growth (Height And Weight) Decreased night appetite and weight loss have been observed in association with the use of ssris and snris. The recommended dose of, cymbalta for treating depression is 20 or 30 mg twice daily or 60 mg once daily.

Cymbalta usa

In a clinical cymbalta pharmacology study designed to evaluate the effects of usa Cymbalta on various parameters, including blood pressure at supratherapeutic doses with an accelerated dose titration, there was evidence of increases in supine blood pressure at doses up to 200 mg twice daily. Give patients the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions cymbalta they may have. When duloxetine was administered (at a dose of 60 mg twice daily) in conjunction with a single 50 mg dose of desipramine, a CYP2D6 substrate, the AUC of desipramine increased 3-fold see Warnings and Precautions (.12 ). The presence of cymbalta metabolites in breast milk was not examined. Periodically reassess to determine the continued need for maintenance treatment and the appropriate dose for such treatment see. When duloxetine was administered orally to pregnant rats and rabbits during the period of organogenesis, there was no usa evidence of teratogenicity at doses up to 45 mg/kg/day (4 times the maximum recommended human dose (mrhd) of 120 mg/day. Patients should be cautioned about the risk usa of bleeding associated with the concomitant use of cymbalta and nsaids, aspirin, or other drugs that affect coagulation. In all 4 studies, cymbalta demonstrated superiority over placebo as usa measured by cymbalta improvement in the 17-item Hamilton Depression Rating Scale (hamd-17) total score (Studies 1-4 in Table 7). Copyright 2009, usa 2016, Eli Lilly and Company. This is cymbalta very important when an antidepressant medicine is started or when the dose is changed. Dosing In Special Populations Hepatic Impairment Avoid use in patients with chronic liver disease or cirrhosis see warnings AND precautions and Use In Specific Populations. Pooled analyses of short-term placebo-controlled trials of antidepressant drugs (ssris and others) showed that these drugs increase the risk usa of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (ages 18-24) with major depressive disorder (MDD) and other psychiatric disorders. In some instances of urinary retention associated with Cymbalta use, hospitalization and/or catheterization has been needed. Fibromyalgia Approximately.5 (227/1294) of the patients who cymbalta received Cymbalta in 3 to 6 month placebo-controlled trials for FM discontinued treatment due to an adverse reaction, compared with.1 (96/955) for placebo. Cymbalta belongs to a class of medicines known as snris (or serotonin-norepinephrine reuptake inhibitors). Management of Overdose There is no specific antidote to Cymbalta, but if serotonin syndrome ensues, specific treatment (such as with cyproheptadine and/or temperature control) may be considered. Cymbalta should be discontinued before initiating treatment with the maoi see Dosage and Administration (.8,.9 and Contraindications ( 4 ). The increased risk appears to be proportional to a patients underlying risk for falls. Seizures Advise patients to inform their physician if they have a history of seizure disorder see Warnings and Precautions (.10 ). Other drugs that inhibit CYP1A2 metabolism include cimetidine and quinolone antimicrobials such as ciprofloxacin and enoxacin cymbalta see warnings AND precautions. The symptoms of over dosage may also contain irregular heart beat, coma, convulsions and severely low blood pressure. Support - cymbalta 24/7 for the life of your dog. If a dose of Cymbalta is missed, take the missed dose as soon as it is remembered. Telephone numbers for certified poison control centers are listed in the Physicians Desk Reference ( PDR ). Drugs That Interfere With Hemostasis (e.g., nsaids, Aspirin, And Warfarin) Serotonin release by platelets plays an important role cymbalta in hemostasis. Patients should be monitored for these symptoms when discontinuing treatment with Cymbalta. Symptoms such as these may be associated with an increased risk for suicidal thinking and behavior and indicate a need for very close monitoring and possibly changes in the medication see BOX warning, and warnings AND precautions. Following abrupt or tapered discontinuation in adult placebo-controlled clinical trials, the following symptoms occurred at 1 or greater and at a significantly higher rate in Cymbalta-treated usa patients compared to those discontinuing from placebo: dizziness, headache, nausea, diarrhea, paresthesia, irritability, vomiting, insomnia, anxiety, hyperhidrosis, and fatigue. The safety and effectiveness of Cymbalta have not been established in pediatric patients less than 18 years of age with other indications. Marketed by: Lilly USA, LLC, Indianapolis, IN 46285, USA. The specific adverse drug reactions observed in adult patients can be expected to be observed in pediatric patients (children and adolescents) see Adverse Reactions Occurring At cymbalta An Incidence Of 2 Or More Among cymbalta-Treated Patients In Adult Placebo-Controlled Trials. Lorazepam Under steady-state conditions for duloxetine (60 mg Q 12 hours) and lorazepam (2 mg Q 12 hours the pharmacokinetics of duloxetine were not affected by co-administration. Elderly people may be at greater risk for this. For more information, call. Please follow the menu links at the left of this page for pictures of our dogs and information about the breed. Diabetes ranks as the seventh leading cause of death in the.S. Therefore, an increase or decrease in the metabolism of CYP3A substrates (e.g., oral contraceptives and other steroidal agents) resulting from induction or inhibition is not anticipated, although clinical studies have not been performed. Use of Cymbalta with Other maois such as Linezolid or Methylene Blue Do not start Cymbalta in a patient who is being treated with linezolid or intravenous methylene blue because there is an increased risk of serotonin syndrome. Dosage For Treatment Of Diabetic Peripheral Neuropathic Pain Administer cymbalta 60 mg once daily. Cymbalta should be discontinued in patients who develop jaundice or other evidence of clinically significant cymbalta liver dysfunction and should not be resumed unless another cause can be established. Males treated with cymbalta experienced more difficulty with ability to reach orgasm (asex Item 4) than males treated with placebo. Table 2: Treatment-Emergent Adverse Reactions: Incidence of 5 or More and Greater than Placebo in Placebo-Controlled Trials of Approved Indicationsa Adverse Reaction Percentage of Patients Reporting Reaction cymbalta (N8100) Placebo (N5655) Nauseac 23 8 Headache. Generalized Anxiety Disorder (GAD 3 short-term trials in adults, 1 maintenance trial in adults, and 1 short-term trial in children and adolescents see Clinical Studies (.2 ). Serotonin syndrome symptoms may include mental status changes (e.g., agitation, hallucinations, delirium, and coma autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, cymbalta for ocd incoordination seizures, and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea). Effects on Blood Pressure - Caution patients that cymbalta may cause an increase in blood pressure see warnings AND precautions. Call your healthcare provider right away if you have any of the following symptoms orfeelings, especially if they are new, worse, or worry you. Increase risk of falls, especially in elderly. Do not chew or crush Cymbalta. Keep all follow-up visits with your healthcare provider as scheduled.

Cymbalta without prescription

In the past few years, Cymbalta cymbalta has without been the second most profitable drug in Lillys product line. Urinary Hesitation and Retention Cymbalta is in a class without of without drugs known to affect urethral resistance. Mutagenesis Duloxetine was not mutagenic in the in vitro bacterial reverse mutation assay ( Ames test ) and was not clastogenic in an in vivo chromosomal aberration test in mouse bone marrow cells. Duloxetine undergoes extensive metabolism, but the major circulating metabolites have not been shown to contribute significantly to the pharmacologic activity of without duloxetine. If symptoms of urinary hesitation develop during treatment without with Cymbalta, consideration should be given cymbalta to the possibility that they might be drug-related. If you take too much Cymbalta, call your healthcare provider or prescription poison control center at right away, or get emergency treatment. Serotonin Syndrome Caution patients about the risk of serotonin syndrome with the concomitant use of Cymbalta and other serotonergic agents including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, buspirone, tryptophan, amphetamines, and. Ive been so sick. And feeling like I was a robot! Table 8: Summary of the Primary Efficacy Results for Studies in General Anxiety Disorder Study Number Treatment Group Primary Efficacy Measure Mean Baseline Score cymbalta (SD) LS Mean Change from Baseline (SE) Placebo-subtracted without Differencea (95 CI) Study 1 (HAM-A) cymbalta. In another study, 533 patients meeting DSM -IV criteria prescription for MDD received cymbalta cymbalta 60 mg once daily during an initial 12-week open-label treatment phase. Cymbalta can be given without regard to meals. Females did not experience more sexual dysfunction on Cymbalta than on placebo as prescription measured by asex total score. Severe Skin Reactions - Caution patients that cymbalta may cause serious skin reactions. Table 6 provides the incidence of treatment-emergent adverse reactions in MDD and GAD pediatric placebo-controlled trials that occurred in greater than 2 of patients treated with cymbalta and with an incidence greater than placebo. Dosage For Treatment Of Chronic Musculoskeletal Pain Administer cymbalta 60 mg once daily. The purpose of this registry is to monitor the pregnancy outcomes in women who have been treated with Cymbalta at any time during pregnancy. Patients assigned to cymbalta started treatment in both studies at a dose of 30 mg once daily for one week. Common possible side effects in people who take Cymbalta include: liver damage. Cymbalta appears to be associated with concentration-dependent but not clinically meaningful QT shortening. Because it is possible that cymbalta and alcohol may interact to cause liver injury or that cymbalta may aggravate pre-existing liver disease, cymbalta should not be prescribed to patients with substantial alcohol use or evidence of chronic liver disease. Common Cymbalta side effects may include: dry mouth; drowsiness, dizziness; tired feeling; nausea, constipation, loss of appetite, weight loss; or increased sweating. Drug Interactions Both CYP1A2 and CYP2D6 are responsible for duloxetine metabolism. Both studies compared Cymbalta 60 mg once daily or 120 mg daily (given in divided doses in FM-1 and as a single daily dose in FM-2) with placebo. Do not give Cymbalta to other people, even if without they have the same symptoms that you have. Neither Cymbalta nor an active control (indicated for treatment of pediatric depression) was superior to placebo. Manic episodes: greatly increased energy severe trouble sleeping racing thoughts reckless behavior unusually grand ideas excessive happiness or irritability talking more or faster than usual. Subsequently, completers of this phase were randomized to double-blind treatment with Cymbalta at either 60 mg once daily or 120 mg once daily. Since most physicians do not know this simple trick, it is up to the patient to ask their physician to use the simple method. The efficacy of cymbalta in the treatment of patients 65 years of age cymbalta with generalized anxiety disorder was established in one 10-week flexible-dose, cymbalta randomized, double-blind, placebo-controlled trial in adults 65 years of age meeting the DSM-IV criteria for GAD. Activation of Mania or Hypomania Adequately screen patients with depressive symptoms for risk of bipolar disorder (e.g. Diabetic Peripheral Neuropathic Pain Approximately.9 (117/906) without of the patients who received Cymbalta in placebo-controlled trials for dpnp discontinued treatment due to an adverse reaction, compared with.1 (23/448) for placebo. Use in Patients with Concomitant Illness Clinical experience with Cymbalta in patients with concomitant systemic illnesses is limited. Not without surprisingly, Cymbalta became very successful. Population PK analyses suggest that mild to moderate degrees of renal impairment (estimated CrCl 30-80 mL/min) have no significant effect on duloxetine apparent clearance see Dosage and Administration (.6 ) and Warnings and Precautions (.14 ). Table 4: Treatment-Emergent Adverse Reactions: Incidence of 2 or More and Greater than Placebo in dpnp, FM, OA, and clbp Placebo-Controlled Trialsa Percentage of Patients Reporting Reaction System Organ Class / Adverse Reaction Cymbalta (N3303) Placebo (N2352) Gastrointestinal. Cymbalta is also used to treat or manage: Generalized Anxiety Disorder (GAD) Diabetic Peripheral Neuropathic Pain (dpnp) Fibromyalgia prescription (FM) Chronic Musculoskeletal Pain Who should not take Cymbalta? Nancy in Florida was taking a different antidepressant: citalopram (Celexa). E Also includes hypersomnia and sedation. Growth (Height And Weight) Decreased appetite and weight loss have been observed in association with the use of ssris and snris. Dosage adjustment based on the age of the patient is not necessary. Periodically reassess to determine the continued need for maintenance treatment and the appropriate dose for such treatment see Clinical Studies (.2 ).

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